HCID 13292504, compound → HCID 19847443, compound

HRID 2350930Notes

Reaction equation

HRID 2350930 reaction equation
Br[CH2:2][CH2:3][C:4]1[CH:13]=[CH:12][C:11]2[C:6](=[CH:7][CH:8]=[C:9]([O:14][CH3:15])[CH:10]=2)[CH:5]=1.[CH3:16][NH:17][CH:18]([N:21]1[C:27](=[O:28])[CH2:26][C:25]2[CH:29]=[C:30]([O:35][CH3:36])[C:31]([O:33][CH3:34])=[CH:32][C:24]=2[CH2:23][CH2:22]1)[CH2:19][CH3:20]>>[CH3:16][N:17]([CH:18]([N:21]1[C:27](=[O:28])[CH2:26][C:25]2[CH:29]=[C:30]([O:35][CH3:36])[C:31]([O:33][CH3:34])=[CH:32][C:24]=2[CH2:23][CH2:22]1)[CH2:19][CH3:20])[CH:3]([C:4]1[CH:13]=[CH:12][C:11]2[C:6](=[CH:7][CH:8]=[C:9]([O:14][CH3:15])[CH:10]=2)[CH:5]=1)[CH3:2]

Participants

3

Reactant 2

HCID 13292504HCID 13292504, compoundHCID 17883742HCID 17883742, compound

Product 1

HCID 19847443HCID 19847443, compound

Conditions

Temperature
100 °C

Procedure

A mixture of 0.66 g (2.5 mmol) of 2-(2-bromoethyl)-6-methoxy-naphthalene and 1.46 g (5 mmol) of 3-(N-methyl-amino-prop-3-yl)-7,8-dimethoxy-1,3,4,5-tetrahydro-2H-3-benzazepin-2-one is heated to 100° C. for 90 minutes. After cooling, the crude product is purified over 70 g of aluminium oxide (neutral, activity II-III) with methylene chloride and then with increasing amounts of ethanol (up to 0.25%).

Workup

  1. temperatureAfter cooling
  2. customthe crude product is purified over 70 g of aluminium oxide (neutral, activity II-III) with methylene chloride

Sources & evidence

ORD record
ord-d7b262558b4e40e19e105b6d2e603ff6
Source dataset
uspto-grants-1989_10
Patent number
US04871735

Reaction notes

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