18-Crown-6 → HCID 19847866, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2.61 g (6.9 mmol) of 5-chloro-3-(2-chloro-6-fluorophenyl)-1-(α,α,α-trifluoro-o-tolyl)-1H-1,2,4-triazole, 0.84 g (14.5 mmol) of dry potassium fluoride and 0.23 g (0.9 mmol) of 18-crown-6 in 15 ml of dry sulfolane is heated at 140° C. for 65 hours. The reaction mixture is subsequently cooled and eluted on silica gel (φ 40-63 μm, column: 0 7 cm, height 20 cm) with ethyl acetate/n-hexane (7:13). There is obtained 3-(2-chloro-6-fluorophenyl)-5-fluoro-1-(α,α,α-trifluoro-o-tolyl)-1H-1,2,4-triazole as white crystals, m.p. 68°-70° C.; mass spectrum: 359(100).

Provenance & Evidence