Potassium Hydroxide → HCID 13592048, compound

HRID 2350979Notes

Reaction equation

HRID 2350979 reaction equation
C([O:4][C:5]1[CH:35]=[CH:34][CH:33]=[CH:32][C:6]=1[C:7]([O:9][C:10]1[C:11]([CH3:31])=[C:12]([CH3:30])[C:13]2[O:17][CH:16]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[O:24]C(=O)C)[S:15][C:14]=2[C:28]=1[CH3:29])=[O:8])(=O)C.[OH-].[K+]>CO>[OH:4][C:5]1[CH:35]=[CH:34][CH:33]=[CH:32][C:6]=1[C:7]([O:9][C:10]1[C:11]([CH3:31])=[C:12]([CH3:30])[C:13]2[O:17][CH:16]([C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][C:19]=3[OH:24])[S:15][C:14]=2[C:28]=1[CH3:29])=[O:8]

Participants

4

Reactant 2

HCID 14797Potassium HydroxideHCID 14802165HCID 14802165, compound

Product 1

HCID 13592048HCID 13592048, compoundYield 47%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 282 mg of 5-(o-acetoxybenzoyloxy)-2-(o-acetoxyphenyl)-4,6,7-trimethyl-1,3-benzoxathiole, 290 mg of potassium hydroxide and 3 ml of methanol was reacted at 10° C. for 12 hours. Subsequent treatment of the reaction mixture was conducted in the same manner as in Example 40. From the fraction eluted with a 50:1 by volume mixture of benzene and ethyl acetate from a silica gel chromatography column were obtained 110 mg of the title compound.

Workup

  1. customwas reacted at 10° C. for 12 hours
  2. washFrom the fraction eluted with a 50:1 by volume mixture of benzene and ethyl acetate from a silica gel chromatography column

Sources & evidence

ORD record
ord-1177e0a72da348d49626b4903335a41c
Source dataset
uspto-grants-1989_10
Patent number
US04871762

Reaction notes

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