Acetic Acid → HCID 14802187, compound

Participants

Reaction Steps

3.6 g of 5-(5-t-butyldimethylsilyloxy-4,6,7-trimethyl-1,3-benzoxathiole-2-yl)-2,2-dimethylpentanoic acid (prepared as described in Example 80), 14.2 g of tetrabutylammonium fluoride trihydrate and 4.9 g of acetic acid were dissolved in 50 ml of tetrahydrofuran, and the mixture was reacted for 20 hours at room temperature. The reaction mixture was then condensed by evaporation under reduced pressure, and the residue was dissolved in ethyl acetate. The ethyl acetate solution was washed with water and dried over anhydrous sodium sulfate, after which the ethyl acetate was distilled off under reduced pressure. The resulting crude product was subjected to silica gel column chromatography. The title compound was obtained from the fraction eluted with a 9:1 by volume mixture of benzene and ethyl acetate.

Provenance & Evidence