Hydrochloric Acid → HCID 178482827, compound

Participants

Reaction Steps

9.4 g of N-[2-hydroxy-2-(4-hydroxyphenyl)ethyl]-N'-methanesulfonyl-N"-[2-[[5-[N-methyl-N(trichloroacetyl)aminomethyl]-2-furyl]methylthio]ethyl]guanidine was dissolved in a mixture of 8 ml of ethanol and 47 ml of a 1N aqueous sodium hydroxide solution in a nitrogen atmosphere. The mixture was stirred at room temperature for 2 hours. Then, the mixture was adjusted to pH 9.7 with 6N hydrochloric acid with ice-cooling, a seed crystal was added thereto and the mixture was stirred for 4 hours at room temperature. The crystals deposited were collected by filtration to obtain 6.0 g (yield: 84%) of N-[2-hydroxy-2-(4hydroxyphenyl)ethyl]-N'-methanesulfonyl-N"-[2-[[5-(methylamino)methyl-2-furyl]methylthio]ethyl]guanidine.

Provenance & Evidence