1-Methylpiperazine → HCID 13852427, compound

Participants

Reaction Conditions

Reaction Steps

In 3 ml of dimethyl sulfoxide was dissolved 60 mg of 1-(2-fluorocyclopropyl)-6,7,8-trifluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid. After addition of 100 mg of N-methylpiperazine, the mixture was stirred at 110° C. for 1 hour. The solvent was removed, and the residue was distributed between chloroform and water. The chloroform layer was dried, and the solvent was removed by distillation. The residue was crystallized from chloroform-ethanol to yield 25 mg of the product. m.p. 251°-253° C. (dec.)

Provenance & Evidence