3-[[[4,5-Bis(phenylmethoxy)-2-pyridinyl]carbonyl]amino]-tetrahydro-2-oxo-1(2H)-pyrimidinecarboxamide → 3-[[(1,4-Dihydro-5-hydroxy-4-oxo-2-pyridinyl)carbonyl]-amino]tetrahydro-2-oxo-1(2H)-pyrimidinecarboxamide

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Reaction Steps

3-[[[4,5-bis(phenylmethoxy)-2-pyridinyl]carbonyl]amino]-tetrahydro-2-oxo-1(2H)-pyrimidinecarboxamide (27.45 g, 57.7 mmol), dissolved in 750 ml N,N-dimethylformamide, was hydrogenated for 1.5 hours over 10 g palladium on activated carbon. The catalyst was removed by filtration and the solvent distilled off in vacuo. The residue was triturated twice with ether to give two batches (15.5 g and 4.0 g) of the desired product, melting point 215°-220° C.

Provenance & Evidence