Sucrose → HCID 14061412, compound

Participants

Reaction Conditions

Reaction Steps

A solution of sucrose (15 g) in 0.lM phosphate buffer (pH7, 100 ml) was warmed to 30° C., and baker's yeast (7.0 g) was added, then shaken for 15 min at 30° C. An emulsion of (1SR,5RS)-2-ethoxycarbonyl-7,7-ethylenedioxybicyclo[3.3.0]octan-3-one (VIII) (498 mg) in 0.2% Triton X-100 (15 ml) was added and the mixture was shaken at 30° C. Sucrose (10 g) was added after 8 hours and successively sucrose (10 g) and baker's yeast (3.5 g) were added after 24 and 48 hours, then the mixture was shaken for 72 hours. Procedure similar to that of Referential Example 1 gave 109 mg of (1S,5R)-2-ethoxycarbonyl-7,7-ethylenedioxybicyclo-[3.3.0]octan-3-one (IV).

Provenance & Evidence