Formic Acid → 7-Formamido-3-methylenecepham-4-carboxylic acid

Participants

Reaction Conditions

Reaction Steps

A mixture of formic acid (1 l) and acetic anhydride (2.5 l) was stirred at 50° C. for 1 hour and cooled at 40°C. To the mixture were added 7-amino-3-methylenecepham-4-carboxylic acid (1,070 g) and N,N-dimethylformamide (500 ml). The mixture was stirred for 1 hour at 55° C. and cooled in an ice-water bath. A resultant precipitate was collected by filtration and washed with a small amount of a mixture of ethyl acetate and diisopropyl ether (1:1) to give 7-formamido-3-methylenecepham-4-carboxylic acid (1.02 g).

Provenance & Evidence