Methylhydrazine → HCID 14128011, compound

Participants

Reaction Steps

In 50 ml of acetonitrile is dissolved 7.5 g of ethyl 2-acetyl-3,3-bis(methylthio)acrylate. To the solution is added dropwise, while stirring at room temperature (15° C.), 1.8 g of methyl hydrazine over a period of 10 minutes, followed by heating for 7 hours under reflux. After completion of the reaction, the solvent is distilled off under reduced pressure. The residue is purified by means of silica gel column chromatography (eluent, n-hexane:ethyl acetate =4/1 to 2/1) to give 4.1 g of the title compound as an oil.

Provenance & Evidence