Methylhydrazine → HCID 14128012, compound

Participants

Reaction Steps

In 60 ml of acetonitrile is dissolved 10.0 g of ethyl 2-acetyl-3,3-bis(benzylthio)acrylate. To the solution is added dropwise, while stirring at room temperature (15° C.), 1.2 g of methyl hydrazine over a period of 10 minutes, followed by heating for 3 hours under reflux. Then, the solvent is distilled off under reduced pressure. The residue is purified by means of silica gel column chromatography (eluent, n-hexane:ethyl acetate=8/1) to give 5.8 g of the title compound as white crystals, m.p. 55° to 56° C.

Provenance & Evidence