HCID 178498315, compound → HCID 12178619, compound

Participants

Reaction Steps

Dimethyl 2-hydroxypyrimidine-4,6-dicarboxylate (1.42 g. 6.7 mmol) was dissolved in methanol (300 ml) and hydrogenated over 10% Pd/C catalyst. The reaction mixture was filtered and the methanol removed under reduced pressure. The crude product was recrystalized from methanol/ether to yield (4R*, 6R*)-dimethyl 2-oxo-hexahydropyrimidine-4,6-dicarboxylate (1.27 g, 88%) as colourless needles m.p. 178°-179°.

Provenance & Evidence