HCID 15703646, compound → HCID 15703647, compound

Participants

Reaction Steps

2-Ethoxycarbonylamino-6-vinyl benzoic acid (500 mg, 2.13 mmol) and 10% Pd-C (50 mg) in 40 ml absolute ethanol was stirred for 16 hrs under 40 psi H2 pressure in a Parr bomb at room temperature. The reaction mixture was filtered through a cone of Celite and the catalyst on Celite was washed with 15 ml ethanol. The combined filtrate was evaporated to dryness. Trituration with ether gave crystalline 2-ethoxycarbonylamino-6-ethylbenzoic acid of Formula (I) in quantitative yield. M.p. 71.5°-74.0° C.; IR (KBr) νmax =1725, 1700 cm-1. Analysis, C12H15NO4 : theory, C 60.75; H 6.37; H 5.90; found, C 60.82; H 6.38; N 5.88.

Provenance & Evidence