HCID 13827107, compound → HCID 13827108, compound

Participants

Reaction Steps

A solution of ethyl 2-ethoxycarbonylamino-4-nitro-6-ethyl-benzoate in tetrahydrofuran (10 ml) and sodium hydroxide (20 ml, 10%) was stirred at room temperature for 20 hours. The solution was extracted with ethyl acetate. The aqueous layer was acidified to pH=1 with 6M HCl, and then immediately extracted with ethylacetate. The ethyl acetate extract was washed with water and dried over magnesium sulphate. Solvent evaporation gave a solid which was further recrystallized from methylene chloride: petroleum ether to yield 2-ethoxycarbonylamino-4-nitro-6-ethyl benzoic acid, m.p. 121°-123° C. as orange crystals. IR νmax : 1665, 1720, 1620, 1510, 2500-3200(br), 3500cm.

Provenance & Evidence