Dicyclohexylcarbodiimide → HCID 54544075, compound

Participants

Reaction Conditions

Reaction Steps

3-(2-Benzimidazolylthio)-3-(2-pyridyl)propionic acid (3.7 g) was suspended in dichloromethane (100 ml) and was cooled to 0° C. N,N'-Dicyclohexylcarbodiimide (2.55 g) was added and the mixture was left to stir until t.l.c. showed no starting material. The solvent was removed under reduced pressure and the residue suspended in acetone and filtered. The solvent was removed under reduced pressure and the residue was dissolved in chloroform. The organic solution was washed with dilute sodium hydrogen carbonate solution then water and was dried (MgSO4). The residue was purified on silica using chloroform as eluent to give 2,3 dihydro-2-(2-pyridyl)-[1,3]-thiazino[3,2-a]benzimidazol-4-one 1/4 hydrate (1.8 g,) mp 165.5°-167.5° C. decomp.

Provenance & Evidence