HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → Benzimidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-Chlorobenzimidazole | HCID 78572 | — |
| Reactant | 2-Bromoacetyl-4-ethylthio-3-methylpyridine | HCID 14421553 | — |
| Product | Benzimidazole | HCID 5798 | — |
Reaction Steps
2-Chlorobenzimidazole is reacted with 2-bromoacetyl-4-ethylthio-3-methylpyridine in the presence of K2CO3 to give 2-chloro-1-[2-[4-ethylthio-3-methylpyridyl])-2-oxoethyl]benzimidazole. This is reacted with thiourea and treated with NH4OH to give 2-mercapto-1-(2-(2-(4-ethylthio-3-methylpyridyl))-2-oxoethyl)benzimidazole. Reduction of this product using NaBH4 gives 1-[2-hydroxy-2-(4-ethylthio-3-methylpyrid-2-yl)ethyl]-2-mercaptobenzimidazole.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04873237 |
| Source dataset | uspto-grants-1989_10 |
| ORD ID | ord-7f981be76bdd4f5ab91db36ab0fe990e |
| Source note | uspto-grants-1989_10 |