反应详情

The mixture of 12.05 g of 5-hydroxymethyl-3-methoxy-isoxazole and 43 g of thionylchloride is heated to reflux for 30 minutes. After cooling, the reaction mixture is poured slowly over crushed ice and is extracted with ether. The organic phase is separated, washed with water and the solution is dried over magnesium sulfate. The solvent is evaporated then distilled in vacuo. 9.64 g of the expected product are obtained.

1. temperatureis heated
2. temperatureto reflux for 30 minutes
3. temperatureAfter cooling
4. additionthe reaction mixture is poured slowly
5. customover crushed ice
6. extractionis extracted with ether
7. customThe organic phase is separated
8. washwashed with water
9. dry with materialthe solution is dried over magnesium sulfate
10. customThe solvent is evaporated
11. distillationthen distilled in vacuo