Methylamine → HCID 66569551, compound

Participants

Reaction Steps

2-chloro-3-nitro-pyridine (16g) was dissolved in dry tetrahydrofuran (200ml). The solution was exposed to gaseous methylamine untill the reaction to N-methylamino-3-nitropyridine was completed. The mixture was filtered and the filtrate was evaporated. The yellow residue was dissolved in 96% EtOH (250ml) and was charged with 5% Pd/C (1 g) and hydrogenated under standard conditions. After completion of the hydrogenation an aqueous solution of hydrochloric acid was added (5Oml,4N), the Pd catalyst was filtered of and the filtrate was evaporated to give the title compound as an oil.

Provenance & Evidence