Water → 3-Deoxyviridicatin

Participants

Reaction Steps

A mixture of o-amino benzophenone (10 g) and acetic acid anhydride (10 ml) in tetrahydrofuran (150 ml) was refluxed for 8 hours. The mixture was thereafter evaporated and the residue was partitioned between sat NaHC03, (20ml) and diethylether (l5Oml). The organic phase was dried and evaporated to give an yellow oil which was redissolved in dimethyl formamide (150ml). To this solution was added NaH (5g) and the mixture was stirred at ll0° C. for 11/2 hour, whereafter it was cooled to room temperature, and poured into water (300ml). This treatment afforded a precipitate of the title compound as pale crystals, which were collected by filtration. The crystals were washed with water and dried. M.p.244°-247° C..

Provenance & Evidence