HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hexane → HCID 14623122, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hexane | HCID 8058 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | Sodium Methoxide | HCID 10942334 | — |
| Reactant | 6-Methylpyridine-2-carboximidamide--hydrogen chloride (1/1) | HCID 14253201 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | HCID 53395939 | HCID 53395939 | — |
| Product | HCID 14623122 | HCID 14623122 | — |
Reaction Steps
To the mixture of 6-methyl-2-picoline amidine hydrochloride (1.5 g) and methanol (50 ml) were added 28% sodium methoxide solution in methanol (2.2 g) and 3-dimethylamino-1-phenyl-2-butene-1-one (1.7 g). After the mixture was heated under reflux for 2 hours, it was concentrated under reduced pressure. The residue obtained was subjected to silica gel column chromatography (eluent; n-hexane:ethylacetate=2:1 in volume) to obtain 2-(6-methyl-2-pyridinyl)-4-phenylpyrimidine (1.6 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04873248 |
| Source dataset | uspto-grants-1989_10 |
| ORD ID | ord-eee5e4b5f08a4bdd9187e5b1378f4f5a |
| Source note | uspto-grants-1989_10 |