Acetic Acid → HCID 45079923, compound

HRID 2351337Notes

Reaction equation

HRID 2351337 reaction equation
[C:1]([C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([CH3:9])[N:4]=1)#[N:2].C[O-].[Na+].[C:13](O)(=[O:15])C>CO>[CH3:9][C:5]1[N:4]=[C:3]([C:1](=[NH:2])[O:15][CH3:13])[CH:8]=[CH:7][CH:6]=1

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 741826-Methylpyridine-2-carbonitrileHCID 10942334Sodium Methoxide

Product 1

HCID 45079923HCID 45079923, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

To the solution of 2-cyano-6-methylpyridine (30 g) and methanol (300 ml) was added 28% sodium methoxide solution in methanol (14.7 g). After the solution was left to stand for 3 hours, acetic acid (4.6 g) was added thereto, followed by concentration under reduced pressure. The resultant residue was dissolved in ether (300 ml) and washed with water (100 ml). After the extract was dried over anhydrous magnesium sulfate, it was concentrated under reduced pressure to obtain methyl 6-methyl-2-picoline imidate.

Workup

  1. waitAfter the solution was left
  2. concentrationfollowed by concentration under reduced pressure
  3. dissolutionThe resultant residue was dissolved in ether (300 ml)
  4. washwashed with water (100 ml)
  5. dry with materialAfter the extract was dried over anhydrous magnesium sulfate, it
  6. concentrationwas concentrated under reduced pressure

Sources & evidence

ORD record
ord-dccd296e103e43769b1e48653e1eeac7
Source dataset
uspto-grants-1989_10
Patent number
US04873248

Reaction notes

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