Acetic Acid → HCID 178424663, compound

Participants

Reaction Steps

6-Methyl-2-picoline amidine hydrochloride (5 g) was dissolved in a solution of sodium methoxide in ethanol prepared from ethanol (50 ml) and metallic sodium (0.8 g). Ethyl o-chlorobenzoyl acetate (7.3 g) was added to the solution obtained above, then the mixture was heated uner reflux for 1 hour. After the reaction mixture was cooled to room temperature, it was neutralized with acetic acid and then concentrated under reduced pressure. The residue obtained was washed with water and n-hexane to obtain 4-o-chlorophenyl-6-hydroxy-2-(6-methyl-2-pyridinyl)pyrimidine (7 g).

Provenance & Evidence