1,1,1-Trimethoxy-2-methylpropane → N-(1-Methoxy-2-methylpropylidene)-3-phenyl-1,2,4-thiadiazole-5-sulfonamide

Participants

Reaction Steps

A mixture of 3 g of 3-phenyl-1,2,4-thiadiazole-5-sulfonamide and and 11 ml of trimethyl orthoisobutyrate was warmed to about 90° using an oil bath. After 2.5 hours, the solution was allowed to cool to room temperature, whereupon a precipitate formed. Hexane (25 ml) was added to complete the precipitation. The solid was collected, washed with hexane and vacuum dried (P2O5) to give 3.34 g of solid, m.p. 123°-124°.

Provenance & Evidence