HuagongsheHuagongshe Chemistry Print Report · For research reference only
11-chlorocarbonyl-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one → 11-[[[3-[2-[(Diethylamino)methyl]-piperidin-1-yl]propyl]amino]carbonyl]-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 11-chlorocarbonyl-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one | HCID 11043962 | — |
| Reactant | 3-[2-[(Diethylamino)methyl]-piperidin-1-yl]propanamine | HCID 14210001 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 11-[[[3-[2-[(Diethylamino)methyl]-piperidin-1-yl]propyl]amino]carbonyl]-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one | HCID 14210029 | 47% |
Reaction Steps
Prepared analogously to Example 2 from 11-(chlorocarbonyl)-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one and 3-[2-[(diethylamino)methyl]-piperidin-1-yl]propanamine in a yield of 47% of theory. Colourless crystals, m.p. 160°-161° C. (acetonitrile).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04873236 |
| Source dataset | uspto-grants-1989_10 |
| ORD ID | ord-96731d50c6d943d9a5780cb8ca203859 |
| Source note | uspto-grants-1989_10 |