HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropyl Ether → 5,10-Dihydro-5-[[[2-[2-[(dimethylamino)methyl]-piperidin-1-yl]ethyl]amino]carbonyl]-11H-dibenzo[b,e][1,4]diazepin-11-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropyl Ether | HCID 7914 | — |
| Reactant | 5-chlorocarbonyl-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one | HCID 13276745 | — |
| Reactant | 2-(2-Dimethylaminomethyl-piperidin-1-yl)-ethylamine | HCID 14210002 | — |
| Product | 5,10-Dihydro-5-[[[2-[2-[(dimethylamino)methyl]-piperidin-1-yl]ethyl]amino]carbonyl]-11H-dibenzo[b,e][1,4]diazepin-11-one | HCID 14210076 | 73% |
Reaction Steps
Prepared analogously to Example 2 from 5-(chlorocarbonyl)-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one and 2-[2-[(dimethylamino)methyl]-piperidin-1-yl]ethanamine in a yield of 73% of theory. Colourless crystals, m.p. 152°-154° C. (diisopropylether).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04873236 |
| Source dataset | uspto-grants-1989_10 |
| ORD ID | ord-fa3110ebc8624b369ca40a1680d698ed |
| Source note | uspto-grants-1989_10 |