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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2351397Generated: November 1, 2026

2-[2-[(Dipropylamino)methyl]-piperidin-1-yl]ethanamine → AF-DX-384

https://huagongshe.com/reaction/2351397

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-[2-[(Dipropylamino)methyl]-piperidin-1-yl]ethanamineHCID 10868438—
Reactant11-chlorocarbonyl-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-oneHCID 11043962—
SolventAcetonitrileHCID 6342—
ProductAF-DX-384HCID 11935788%

Reaction Steps

Prepared analogously to Example 2 from 11-(chlorocarbonyl)-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one and 2-[2-[(dipropylamino)methyl]-piperidin-1-yl]ethanamine in a yield of 88% of theory. Colourless crystals, m.p. 165° C. (acetonitrile).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04873236
Source datasetuspto-grants-1989_10
ORD IDord-bcd4dcd613cb4c9b90533e97e9c8dc9f
Source noteuspto-grants-1989_10