HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-[2-[(Dipropylamino)methyl]-piperidin-1-yl]ethanamine → 5,11-Dihydro-11-[[[2-[2-[(dipropylamino)methyl]-piperidin-1-yl]ethyl]amino]carbonyl]-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-[2-[(Dipropylamino)methyl]-piperidin-1-yl]ethanamine | HCID 10868438 | — |
| Reactant | 11-chlorocarbonyl-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one | HCID 11043962 | — |
| Solvent | Water | HCID 962 | — |
| Product | 5,11-Dihydro-11-[[[2-[2-[(dipropylamino)methyl]-piperidin-1-yl]ethyl]amino]carbonyl]-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one hydrochloride | HCID 19845942 | 87% |
Reaction Steps
Prepared analogously to Example 1 from 11-(chlorocarbonyl)-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one and 2-[2-[(dipropylamino)methyl]-piperidin-1-yl]ethanamine in a yield of 87% of theory. Colourless crystals, m.p. 197°-199° C., not readily soluble in water.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04873236 |
| Source dataset | uspto-grants-1989_10 |
| ORD ID | ord-86f296ca73674e5fa1632ddd2a753d48 |
| Source note | uspto-grants-1989_10 |