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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2351405Generated: November 1, 2026

2-[2-[(Dipropylamino)methyl]-piperidin-1-yl]ethanamine → 6,11-Dihydro-11-[[[2-[2-[(dipropylamino)methyl]-piperidin-1-yl]ethyl]amino]carbonyl]-5H-pyrido[2,3-b][1,5]benzodiazepin-5-one

https://huagongshe.com/reaction/2351405

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-[2-[(Dipropylamino)methyl]-piperidin-1-yl]ethanamineHCID 10868438—
Reactant11-(chlorocarbonyl)-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-5-oneHCID 14209983—
SolventAcetonitrileHCID 6342—
Product6,11-Dihydro-11-[[[2-[2-[(dipropylamino)methyl]-piperidin-1-yl]ethyl]amino]carbonyl]-5H-pyrido[2,3-b][1,5]benzodiazepin-5-oneHCID 1421008366%

Reaction Steps

Prepared analogously to Example 2 from 11-(chlorocarbonyl)-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-5-one and 2-[2-[(dipropylamino)methyl]-piperidin-1-yl]ethanamine in a yield of 66% of theory. Colourless crystals, m.p. 149°-151° C. (acetonitrile).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04873236
Source datasetuspto-grants-1989_10
ORD IDord-0d53aea3b4ac432fb0c89643d57a42f2
Source noteuspto-grants-1989_10