2-[2-[(Dipropylamino)methyl]-piperidin-1-yl]ethanamine → 3-Chloro-4-[[[2-[2-[(dipropylamino)methyl]-piperidin-1-yl]ethyl]amino]carbonyl]-1-methyl-1,4,9,10-tetrahydro-pyrrolo[3,2-b][1,5]benzodiazepin-10-one

HRID 2351411Notes

Reaction equation

HRID 2351411 reaction equation
[Cl:1][C:2]1[C:6]2[N:7]([C:17](Cl)=[O:18])[C:8]3[CH:16]=[CH:15][CH:14]=[CH:13][C:9]=3[NH:10][C:11](=[O:12])[C:5]=2[N:4]([CH3:20])[CH:3]=1.[CH2:21]([N:24]([CH2:28][CH:29]1[CH2:34][CH2:33][CH2:32][CH2:31][N:30]1[CH2:35][CH2:36][NH2:37])[CH2:25][CH2:26][CH3:27])[CH2:22][CH3:23]>>[Cl:1][C:2]1[C:6]2[N:7]([C:17]([NH:37][CH2:36][CH2:35][N:30]3[CH2:31][CH2:32][CH2:33][CH2:34][CH:29]3[CH2:28][N:24]([CH2:21][CH2:22][CH3:23])[CH2:25][CH2:26][CH3:27])=[O:18])[C:8]3[CH:16]=[CH:15][CH:14]=[CH:13][C:9]=3[NH:10][C:11](=[O:12])[C:5]=2[N:4]([CH3:20])[CH:3]=1

Participants

3

Reactant 2

HCID 108684382-[2-[(Dipropylamino)methyl]-piperidin-1-yl]ethanamineHCID 151069253-Chloro-4-(chlorocarbonyl)-1-methyl-1,4,9,10-tetrahydro-pyrrolo[3,2-b][1,5]benzodiazepin-10-one

Product 1

HCID 142100783-Chloro-4-[[[2-[2-[(dipropylamino)methyl]-piperidin-1-yl]ethyl]amino]carbonyl]-1-methyl-1,4,9,10-tetrahydro-pyrrolo[3,2-b][1,5]benzodiazepin-10-oneYield 57%

Procedure

Prepared analogously to Example 2 from 3-chloro-4-(chlorocarbonyl)-1-methyl-1,4,9,10-tetrahydro-pyrrolo[3,2-b][1,5]benzodiazepin-10-one and 2-[2-[(dipropylamino)methyl]-piperidin-1-yl]ethanamine in a yield of 57% of theory.

Sources & evidence

ORD record
ord-aadfe372169f48808dbee992001a9241
Source dataset
uspto-grants-1989_10
Patent number
US04873236

Reaction notes

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