HuagongsheHuagongshe Chemistry Print Report · For research reference only
9-Chloro-11-(chlorocarbonyl)-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one → 9-Chloro-11-[[[2-[3-[(diethylamino)methyl]-piperidin-1-yl]-ethyl]amino]carbonyl]-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 9-Chloro-11-(chlorocarbonyl)-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one | HCID 14209976 | — |
| Reactant | 2-[3-[(Diethylamino)methyl]-piperidin-1-yl]ethanamine | HCID 14210022 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 9-Chloro-11-[[[2-[3-[(diethylamino)methyl]-piperidin-1-yl]-ethyl]amino]carbonyl]-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one | HCID 14210066 | 73% |
Reaction Steps
Prepared analogously to Example 46 from 9-chloro-11-(chlorocarbonyl)-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one and 2-[3-[(diethylamino)methyl]-piperidin-1-yl]ethanamine in a yield of 73% of theory. Colourless crystals, m.p. 125° C. (D.) (acetonitrile).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04873236 |
| Source dataset | uspto-grants-1989_10 |
| ORD ID | ord-b6a86cdbb561419a9958cae4608ebde4 |
| Source note | uspto-grants-1989_10 |