Acetonitrile → HCID 14210063, compound

HRID 2351418Notes

Reaction equation

HRID 2351418 reaction equation
Cl[C:2]([N:4]1[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=2[C:8](=[O:15])[NH:7][C:6]2[CH:16]=[CH:17][CH:18]=[N:19][C:5]1=2)=[O:3].[CH2:20]([N:22]([CH2:25][CH:26]1[CH2:30][CH2:29][N:28]([CH2:31][CH2:32][NH2:33])[CH2:27]1)[CH2:23][CH3:24])[CH3:21].[C:34](#N)C>>[CH2:23]([N:22]([CH2:25][CH:26]1[CH2:30][CH2:34][CH2:29][N:28]([CH2:31][CH2:32][NH:33][C:2]([N:4]2[C:10]3[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=3[C:8](=[O:15])[NH:7][C:6]3[CH:16]=[CH:17][CH:18]=[N:19][C:5]2=3)=[O:3])[CH2:27]1)[CH2:20][CH3:21])[CH3:24]

Participants

4

Reactant 3

HCID 6342AcetonitrileHCID 1104396211-chlorocarbonyl-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-oneHCID 19846080HCID 19846080, compound

Product 1

HCID 14210063HCID 14210063, compoundYield 32%

Procedure

Prepared analogously to Example 2 from 11-(chlorocarbonyl)-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one and 2-[3-[(diethylamino)methyl]-pyrrolidin-1-yl]ethanamine in a yield of 32% of theory. Colourless crystals, m.p. 184°-185° C. (acetonitrile).

Sources & evidence

ORD record
ord-a6a8729a88ed4e4091e624752bf07eff
Source dataset
uspto-grants-1989_10
Patent number
US04873236

Reaction notes

Loading…