11-chlorocarbonyl-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one → HCID 14210071, compound

HRID 2351423Notes

Reaction equation

HRID 2351423 reaction equation
Cl[C:2]([N:4]1[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=2[C:8](=[O:15])[NH:7][C:6]2[CH:16]=[CH:17][CH:18]=[N:19][C:5]1=2)=[O:3].[N:20]1([CH2:25][CH:26]2[CH2:31][CH2:30][CH2:29][CH2:28][N:27]2[CH2:32][CH2:33][NH2:34])[CH2:24][CH2:23][CH2:22][CH2:21]1>C(#N)C>[N:20]1([CH2:25][CH:26]2[CH2:31][CH2:30][CH2:29][CH2:28][N:27]2[CH2:32][CH2:33][NH:34][C:2]([N:4]2[C:10]3[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=3[C:8](=[O:15])[NH:7][C:6]3[CH:16]=[CH:17][CH:18]=[N:19][C:5]2=3)=[O:3])[CH2:21][CH2:22][CH2:23][CH2:24]1

Participants

4

Reactant 2

HCID 1104396211-chlorocarbonyl-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-oneHCID 14210016HCID 14210016, compound

Product 1

HCID 14210071HCID 14210071, compoundYield 44%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Prepared analogously to Example 2 from 11-(chlorocarbonyl)-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one and 2-[2-[(pyrrolidin-1-yl)methyl]-piperidin-1-yl]ethanamine in a yield of 44% of theory. Colourless crystals, m.p. 198° C. (from acetonitrile using fuller's earth).

Sources & evidence

ORD record
ord-cf354484ef724500a874cbf659747f71
Source dataset
uspto-grants-1989_10
Patent number
US04873236

Reaction notes

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