HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrafluoro-m-phenylenediamine dihydrochloride → 5,11-Dihydro-11-[[[2-[4-[4-(piperidin-1-yl)butyl]-piperidin-1-yl]ethyl]amino]carbonyl]-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrafluoro-m-phenylenediamine dihydrochloride | HCID 149026 | — |
| Reactant | 11-chlorocarbonyl-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one | HCID 11043962 | — |
| Reactant | HCID 19845995 | HCID 19845995 | — |
| Product | 5,11-Dihydro-11-[[[2-[4-[4-(piperidin-1-yl)butyl]-piperidin-1-yl]ethyl]amino]carbonyl]-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one dihydrochloride | HCID 19846014 | 40% |
Reaction Steps
Prepared analogously to Example 46 from 11-(chlorocarbonyl)-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one and 2-[4-[4-(piperidin-1-yl)butyl]-piperidin-1-yl]ethanamine in a yield of 40% of theory. The colourless dihydrochloride melted at 231°-233° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04873236 |
| Source dataset | uspto-grants-1989_10 |
| ORD ID | ord-ed29a396f8b44f5f8139cc01967b251a |
| Source note | uspto-grants-1989_10 |