HuagongsheHuagongshe Chemistry Print Report · For research reference only
11-(chlorocarbonyl)-5,11-dihydro-9-methyl-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one → 11-[[[2-[4-[3-[Bis(methylethyl)amino]propyl]-piperidin-1-yl]ethyl]amino]carbonyl]-5,11-dihydro-9-methyl-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 11-(chlorocarbonyl)-5,11-dihydro-9-methyl-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one | HCID 15107471 | — |
| Reactant | 2-[4-[3-[Bis(methylethyl)amino]propyl]-piperidin-1-yl]ethanamine | HCID 19845945 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 11-[[[2-[4-[3-[Bis(methylethyl)amino]propyl]-piperidin-1-yl]ethyl]amino]carbonyl]-5,11-dihydro-9-methyl-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one | HCID 19846013 | 46% |
Reaction Steps
Prepared analogously to Example 1 from 11-(chlorocarbonyl)-5,11-dihydro-9-methyl-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one and 2-[4-[3-[bis(methylethyl)amino]propyl]-piperidin-1-yl]ethanamine in a yield of 46% of theory. Colourless crystals, m.p. 160°-162° C. (ethyl acetate).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04873236 |
| Source dataset | uspto-grants-1989_10 |
| ORD ID | ord-6d4c5d3fe212426583340f9d730fd35d |
| Source note | uspto-grants-1989_10 |