HuagongsheHuagongshe Chemistry Print Report · For research reference only
9-Chloro-11-(chlorocarbonyl)-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one → 11-[[[2-[4-[3-[Bis(methylethyl)amino]propyl]-piperidin-l-yl]ethyl]amino]carbonyl]-9-chloro-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 9-Chloro-11-(chlorocarbonyl)-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one | HCID 14209976 | — |
| Reactant | 2-[4-[3-[Bis(methylethyl)amino]propyl]-piperidin-1-yl]ethanamine | HCID 19845945 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 11-[[[2-[4-[3-[Bis(methylethyl)amino]propyl]-piperidin-l-yl]ethyl]amino]carbonyl]-9-chloro-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one | HCID 54289598 | 44% |
Reaction Steps
Prepared analogously to Example 1 from 9-chloro-11-(chlorocarbonyl)-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one and 2-[4-[3-[bis(methylethyl)amino]propyl]-piperidin-l-yl]ethanamine in a yield of 44% of theory. Colourless crystals, m.p. 175°-176° C. (acetonitrile).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04873236 |
| Source dataset | uspto-grants-1989_10 |
| ORD ID | ord-1adcfe8ab5ca49f8843e6237dfe86df9 |
| Source note | uspto-grants-1989_10 |