HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropyl Ether → 4-[[[2-[4-[3-(Dipropylamino)propyl]-piperidin-l-yl]ethyl]amino]carbonyl]-4,9-dihydro-3-methyl-10H-thieno[3,4-b][1,5]benzodiazepin-10-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropyl Ether | HCID 7914 | — |
| Reactant | 4-chlorocarbonyl-4,9-dihydro-3-methyl-10H-thieno[3,4-b][1,5]benzodiazepin-10-one | HCID 14209980 | — |
| Reactant | 2-[4-[3-(Dipropylamino)propyl]-piperidin-1-yl]ethanamine | HCID 19846011 | — |
| Product | 4-[[[2-[4-[3-(Dipropylamino)propyl]-piperidin-l-yl]ethyl]amino]carbonyl]-4,9-dihydro-3-methyl-10H-thieno[3,4-b][1,5]benzodiazepin-10-one | HCID 54405296 | 42% |
Reaction Steps
Prepared analogously to Example 1 from 4-(chlorocarbonyl)-4,9-dihydro-3-methyl-10H-thieno[3,4-b][1,5]benzodiazepin-10-one and 2-[4-[3-(dipropylamino)propyl]-piperidin-l-yl]ethanamine in a yield of 42% of theory. Colourless crystals, m.p. 114°-115° C. (diisopropyl ether).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04873236 |
| Source dataset | uspto-grants-1989_10 |
| ORD ID | ord-84bbaae2a62a4734ad8a93ae4a94245d |
| Source note | uspto-grants-1989_10 |