4-chlorocarbonyl-4,9-dihydro-3-methyl-10H-thieno[3,4-b][1,5]benzodiazepin-10-one → HCID 53740431, compound

HRID 2351434Notes

Reaction equation

HRID 2351434 reaction equation
Cl[C:2]([N:4]1[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=2[NH:8][C:7](=[O:15])[C:6]2=[CH:16][S:17][C:18]([CH3:19])=[C:5]12)=[O:3].[CH2:20]([N:22]([CH2:35][CH3:36])[CH2:23][CH2:24][CH2:25][CH:26]1[CH2:31][CH2:30][N:29]([CH2:32][CH2:33][NH2:34])[CH2:28][CH2:27]1)[CH3:21]>C(#N)C>[CH2:35]([N:22]([CH2:20][CH3:21])[CH2:23][CH2:24][CH2:25][CH:26]1[CH2:31][CH2:30][N:29]([CH2:32][CH2:33][NH:34][C:2]([N:4]2[C:10]3[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=3[NH:8][C:7](=[O:15])[C:6]3=[CH:16][S:17][C:18]([CH3:19])=[C:5]23)=[O:3])[CH2:28][CH2:27]1)[CH3:36]

Participants

4

Reactant 2

HCID 142099804-chlorocarbonyl-4,9-dihydro-3-methyl-10H-thieno[3,4-b][1,5]benzodiazepin-10-oneHCID 19845952HCID 19845952, compound

Product 1

HCID 53740431HCID 53740431, compoundYield 52%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Prepared analogously to Example 1 from 4-(chlorocarbonyl)-4,9-dihydro-3-methyl-10H-thieno[3,4-b][1,5]benzodiazepin-10-one and 2-[4-[3-(diethylamino)propyl]-piperidin-l-yl]ethanamine in a yield of 52% of theory. Colourless crystals, m.p. 131°-133° C. (acetonitrile).

Sources & evidence

ORD record
ord-b314981da2814e04838c0160bbcaf72e
Source dataset
uspto-grants-1989_10
Patent number
US04873236

Reaction notes

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