HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-chlorocarbonyl-4,9-dihydro-3-methyl-10H-thieno[3,4-b][1,5]benzodiazepin-10-one → 4,9-Dihydro-3-methyl-4-[[[2-[4-[4-(piperidin-l-yl)butyl]-piperidin-l-yl]ethyl]amino]carbonyl]-10H-thieno[3,4-b][1,5]benzodiazepin-10-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-chlorocarbonyl-4,9-dihydro-3-methyl-10H-thieno[3,4-b][1,5]benzodiazepin-10-one | HCID 14209980 | — |
| Reactant | HCID 19845995 | HCID 19845995 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 4,9-Dihydro-3-methyl-4-[[[2-[4-[4-(piperidin-l-yl)butyl]-piperidin-l-yl]ethyl]amino]carbonyl]-10H-thieno[3,4-b][1,5]benzodiazepin-10-one | HCID 53990511 | 20% |
Reaction Steps
Prepared analogously to Example 1 from 4-(chlorocarbonyl)-4,9-dihydro-3-methyl-10H-thieno[3,4-b][1,5]benzodiazepin-10-one and 2-[4-[4-(piperidin-l-yl)butyl]-piperidin-l-yl]ethanamine in a yield of 20% of theory. Colourless crystals, m.p. 186°-187° C. (acetonitrile).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04873236 |
| Source dataset | uspto-grants-1989_10 |
| ORD ID | ord-58ae047251234c4bab5571b269399de5 |
| Source note | uspto-grants-1989_10 |