11-chlorocarbonyl-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one → HCID 54150327, compound

HRID 2351439Notes

Reaction equation

HRID 2351439 reaction equation
Cl[C:2]([N:4]1[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=2[C:8](=[O:15])[NH:7][C:6]2[CH:16]=[CH:17][CH:18]=[N:19][C:5]1=2)=[O:3].[CH3:20][N:21]([CH3:35])[CH2:22][CH2:23][CH2:24][CH2:25][CH:26]1[CH2:31][CH2:30][CH2:29][N:28]([CH2:32][CH2:33][NH2:34])[CH2:27]1>>[CH3:35][N:21]([CH3:20])[CH2:22][CH2:23][CH2:24][CH2:25][CH:26]1[CH2:31][CH2:30][CH2:29][N:28]([CH2:32][CH2:33][NH:34][C:2]([N:4]2[C:10]3[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=3[C:8](=[O:15])[NH:7][C:6]3[CH:16]=[CH:17][CH:18]=[N:19][C:5]2=3)=[O:3])[CH2:27]1

Participants

3

Reactant 2

HCID 1104396211-chlorocarbonyl-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-oneHCID 19845964HCID 19845964, compound

Product 1

HCID 54150327HCID 54150327, compoundYield 53%

Procedure

Prepared analogously to Example 46 from 11-(chlorocarbonyl)-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one and 2-[3-[4-(dimethylamino)butyl]-piperidin-l-yl]ethanamine in a yield of 53% of theory. Colourless crystals, m.p. 119°-120° C.

Sources & evidence

ORD record
ord-fb0b172d82b4445d82a1e564ba270ce5
Source dataset
uspto-grants-1989_10
Patent number
US04873236

Reaction notes

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