HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → HCID 67935679, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Tetrafluoro-m-phenylenediamine dihydrochloride | HCID 149026 | — |
| Reactant | 11-chlorocarbonyl-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one | HCID 11043962 | — |
| Reactant | HCID 19846046 | HCID 19846046 | — |
| Solvent | Dichloromethane ethanol | HCID 21584144 | — |
| Product | HCID 67935679 | HCID 67935679 | 35% |
Reaction Steps
Prepared analogously to Example 46 from 11-(chlorocarbonyl)-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one and 2-[3-[4-(pyrrolidin-l-yl)butyl]-piperidin-l-yl]ethanamine in a yield of 35% of theory. The colourless dihydrochloride melted at 170°-172° C.; RF 0.69 (HPTLC ready-made silica gel plates 60 F254 for Nano-TLC, Messrs Merck; eluant: dichloromethane/ethanol/conc. ammonia 65/30/5 v/v/v).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04873236 |
| Source dataset | uspto-grants-1989_10 |
| ORD ID | ord-3ca7d578e352473094da0f10b8fc967f |
| Source note | uspto-grants-1989_10 |