2-[2-[(Dipropylamino)methyl]-piperidin-1-yl]ethanamine → HCID 54521076, compound

HRID 2351449Notes

Reaction equation

HRID 2351449 reaction equation
[Cl:1][C:2]1[C:12]2[N:11]([C:13](Cl)=[O:14])[C:10]3[CH:16]=[CH:17][CH:18]=[CH:19][C:9]=3[C:8](=[O:20])[NH:7][C:6]=2[CH:5]=[CH:4][CH:3]=1.[CH2:21]([N:24]([CH2:28][CH:29]1[CH2:34][CH2:33][CH2:32][CH2:31][N:30]1[CH2:35][CH2:36][NH2:37])[CH2:25][CH2:26][CH3:27])[CH2:22][CH3:23]>>[Cl:1][C:2]1[C:12]2[N:11]([C:13]([NH:37][CH2:36][CH2:35][N:30]3[CH2:31][CH2:32][CH2:33][CH2:34][CH:29]3[CH2:28][N:24]([CH2:21][CH2:22][CH3:23])[CH2:25][CH2:26][CH3:27])=[O:14])[C:10]3[CH:16]=[CH:17][CH:18]=[CH:19][C:9]=3[C:8](=[O:20])[NH:7][C:6]=2[CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 108684382-[2-[(Dipropylamino)methyl]-piperidin-1-yl]ethanamineHCID 19845957HCID 19845957, compound

Product 1

HCID 54521076HCID 54521076, compoundYield 2.6%

Procedure

Prepared analogously to Example 1 from 6-chloro-5-(chlorocarbonyl)-5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one and 2-[2-[(dipropylamino)methyl]-piperidin-l-yl]ethanamine in a yield of 2.6% of theory. Colourless crystals, m.p. 71°-78° C., presumably a mixture of 2 diastereomers.

Workup

  1. additionColourless crystals, m.p. 71°-78° C., presumably a mixture of 2 diastereomers

Sources & evidence

ORD record
ord-f91c1ce1c6c44b27802c2e9c4ecdd2ec
Source dataset
uspto-grants-1989_10
Patent number
US04873236

Reaction notes

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