HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-[3-(1-Methyl-pyrrolidin-2-yl)propyl]piperidine → 4,9-Dihydro-3-methyl-4-[[[2-[4-[3-(1-methyl-pyrrolidin-2-yl)propyl]-piperidin-l-yl]ethyl]amino]carbonyl]-10H-thieno[3,4-b][1,5]benzodiazepin-10-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-[3-(1-Methyl-pyrrolidin-2-yl)propyl]piperidine | HCID 19804215 | — |
| Reactant | 4-[[[2-bromo-ethyl]amino]carbonyl]-4,9-dihydro-3-methyl-10H-thieno[3,4-b][1,5]benzodiazepin-10-one | HCID 19846026 | — |
| Solvent | Ethanol ethylacetate | HCID 21584252 | — |
| Product | 4,9-Dihydro-3-methyl-4-[[[2-[4-[3-(1-methyl-pyrrolidin-2-yl)propyl]-piperidin-l-yl]ethyl]amino]carbonyl]-10H-thieno[3,4-b][1,5]benzodiazepin-10-one | HCID 54398440 | 18% |
Reaction Steps
Prepared analogously to Example 109 from 4-[[[2-bromo-ethyl]amino]carbonyl]-4,9-dihydro-3-methyl-10H-thieno[3,4-b][1,5]benzodiazepin-10-one and 4-[3-(1-methyl-pyrrolidin-2-yl)propyl]piperidine in a yield of 18% of theory. Colourless crystals, m.p. 145°-146° C. (from ethyl acetate/ethanol). RF =0.5 (TLC investigation as in Example 114).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04873236 |
| Source dataset | uspto-grants-1989_10 |
| ORD ID | ord-fc4226085c3b40ceac1e05ebfcd866cd |
| Source note | uspto-grants-1989_10 |