Boron trifluoride etherate → HCID 9921313, compound

Participants

Reaction Steps

N-benzyloxy-1-(5-fluorobenzo[b]thien-2-yl)ethyl amine. n-Butyl lithium (2.5M in hexanes, 4.4 mL) was added to a solution of 5-fluorobenzothiophene, prepared as described in part a, above (1.52 g, 10 mmole) in THF (25 mL) at -78° C. After stirring for 30 minutes borontrifluoride etherate was added followed by O-benzyl acetaldehyde oxime. Fifteen minutes later aqueous NH4Cl was added and the reaction warmed to room temperature. The aqueous phase was extracted twice with ether and the combined organic layers washed twice with brine, dried over MgSO4 and concentrated. The desired product was obtained as a yellow oil (2.9 g).

Provenance & Evidence