HCID 15671170, compound → HCID 15671171, compound

Participants

Reaction Steps

2.1 g of ethyl 2-[4-(2,4-dioxothiazolidin-5-ylmethyl)phenoxymethyl]-2-methyl-2H-chromene-6-carboxylate (prepared as described in Example 16) were dissolved in 20 ml of acetic acid and hydrogenated for 20 hours under atmospheric pressure at 80° C. in the presence of 2 g of 10% w/w palladium-on-carbon. The catalyst was then removed by filtration, and the filtrate was freed from the solvent by evaporation under reduced pressure. The residue was purified by column chromatography through silica gel, eluted with a 4:1 by volume mixture of benzene and ethyl acetate, to afford 1.17 g of the title compound as a white powder.

Provenance & Evidence