Methanol → HCID 15671138, compound

HRID 2351523Notes

Reaction equation

HRID 2351523 reaction equation
[CH3:1][C:2]1([CH2:16][O:17][C:18]2[CH:23]=[CH:22][C:21]([N+:24]([O-])=O)=[CH:20][CH:19]=2)[CH:11]=[CH:10][C:9]2[C:4](=[C:5]([CH3:15])[C:6]([CH3:14])=[C:7]([CH3:13])[C:8]=2[CH3:12])[O:3]1.CO>[Pd].C1C=CC=CC=1>[NH2:24][C:21]1[CH:22]=[CH:23][C:18]([O:17][CH2:16][C:2]2([CH3:1])[CH2:11][CH2:10][C:9]3[C:4](=[C:5]([CH3:15])[C:6]([CH3:14])=[C:7]([CH3:13])[C:8]=3[CH3:12])[O:3]2)=[CH:19][CH:20]=1

Participants

5

Reactant 2

HCID 887MethanolHCID 15671134HCID 15671134, compound

Product 1

HCID 15671138HCID 15671138, compoundYield 74.3%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 241BenzeneSolvent

Procedure

Following a procedure similar to that described in Preparation 4, 760 mg of 2,5,6,7,8-pentamethyl-2-(4-nitrophenoxymethyl)-2H-chromene (prepared as described in Preparation 31) were hydrogenated, using 100 mg of 10% w/w palladium-on-carbon, 20 ml of methanol and 70 ml of benzene, at atmospheric pressure, to afford 520 mg of the title compound as a pale yellow oil.

Sources & evidence

ORD record
ord-23a20921f66440de81f67fab95aa8e01
Source dataset
uspto-grants-1989_10
Patent number
US04873255

Reaction notes

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