HCID 19846145, compound → HCID 19846138, compound

HRID 2351550Notes

Reaction equation

HRID 2351550 reaction equation
Cl.[NH2:2][CH2:3][C:4]([NH:6][C:7]1([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=2Br)[CH2:15][C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[CH2:8]1)=[O:5].Cl.N[CH2:25][C:26](NC1(C2C=CC(Cl)=CC=2)CC2C(=CC=CC=2)C1)=[O:27].Cl.N[CH2:47][C:48](NC1(C2C=CC=C(C)C=2)CC2C(=CC=CC=2)C1)=O.Cl.NCC(NC1(C2C=CC(C(F)(F)F)=CC=2)CC2C(=CC=CC=2)C1)=O.Cl.NCC(NC1(C2C=CC=C(F)C=2)CC2C(=CC=CC=2)C1)=O.Cl.NCC(NC1(C2C=CC(OC)=CC=2)CC2C(=CC=CC=2)C1)=O.Cl.NCC(NC1(C2C=CC(OC)=C(OC)C=2)CC2C(=CC=CC=2)C1)=O.Cl.NCC(NC1(C2C=CC(F)=CC=2F)CC2C(=CC=CC=2)C1)=O.Cl.CNCC(NC1(C2C=CC(OCCCC)=CC=2)CC2C(=CC=CC=2)C1)=O.Cl.CN(C)CC(NC1(C2C=CC(CCCC)=CC=2)CC2C(=CC=CC=2)C1)=O>>[C:16]1([C:7]2([NH:6][C:4](=[O:5])[CH2:3][N:2]3[CH2:25][CH2:26][O:27][CH2:48][CH2:47]3)[CH2:15][C:14]3[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=3)[CH2:8]2)[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1

Participants

11

Reactant 10

HCID 19846145HCID 19846145, compoundHCID 19846149HCID 19846149, compoundHCID 19846155HCID 19846155, compoundHCID 19846157HCID 19846157, compoundHCID 19846160HCID 19846160, compoundHCID 19846166HCID 19846166, compoundHCID 19846171HCID 19846171, compoundHCID 19846176HCID 19846176, compoundHCID 19846179HCID 19846179, compoundHCID 19846181HCID 19846181, compound

Product 1

HCID 19846138HCID 19846138, compound

Procedure

Application of the methodology described above will provide all the compounds of the invention including, for example, the following compounds: 2-amino-N-[2,3-dihydro-2(2-bromophenyl)-1H-inden-2-yl]acetamide hydrochloride; 2-amino-N-[2,3-dihydro-2-(4-chlorophenyl)-1H-inden-2-yl]acetamide hydrochloride; 2-amino-N-[2,3-dihydro-2-(3-methylphenyl)-1H-inden-2-yl]acetamide hydrochloride; 2-amino-N-[2,3-dihydro-2-[4-(trifluoromethyl)phenyl]-1H-inden-2-yl]acetamide hydrochloride; 2-amino-N-[2,3-dihydro-2-(3-fluorophenyl)-1H-inden-2-yl]acetamide hydrochloride; 2-amino-N-[2,3-dihydro-2-(4-methoxyphenyl)-1H-inden-2-yl]acetamide hydrochloride; 2-amino-N-[2,3-dihydro-2-(3,4-dimethoxyphenyl)-1H-inden-2-yl]acetamide hydrochloride; 2-amino-N-[2,3-dihydro-2-(2,4-difluoro-phenyl)-1H-inden-2-yl]acetamide hydrochloride; 2-(methyl-amino)-N-[2,3-dihydro-2-(4-n-butoxyphenyl)-1H-inden-2yl]acetamide hydrochloride; 2-(dimethylamino)-N-[2,3-dihydro-2-(4-n-butylphenyl)-1H-inden-2-yl]acetamide hydrochloride.

Workup

  1. customApplication of the methodology described above will provide all the compounds of the invention

Sources & evidence

ORD record
ord-cd7a6722a345489aabd4d728121eabb9
Source dataset
uspto-grants-1989_10
Patent number
US04873241

Reaction notes

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