反应详情

A solution of 8-fluoro-6,11-dihydro-11-(1- ethoxycarbonyl-4-piperidylidene)-5H-benzo[5,6]cyclohepta[1,2-b]pyridine (3.6 g, 0.0098 mole) and potassium hydroxide (4.5 g, 0.094 mole) in 50 mL of ethanol:water (1:1) is heated at reflux for 66 hours. The reaction mixture is diluted with brine and the product is extracted into ethyl acetate. The solution is concentrated to a residual solid which is washed with acetone/ethvl acetate to yield 2.76 g (0.0094 mole) of 8- fluoro-11-(4-piperidylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine.

1. temperatureat reflux for 66 hours
2. extractionthe product is extracted into ethyl acetate
3. concentrationThe solution is concentrated to a residual solid which
4. washis washed with acetone/ethvl acetate