HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-bromobutanimide → 4-Bromo-2,6-difluoroaniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-bromobutanimide | HCID 67184 | — |
| Reactant | 2,6-Difluoroaniline | HCID 79647 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 4-Bromo-2,6-difluoroaniline | HCID 610191 | 62% |
Reaction Steps
Fifty grams (0.39 mole) of 2,6-difluoroaniline was treated with 71.0 g (0.39 mole) of N-bromosuccinimide in 250 ml of dimethylformamide by the procedure of Mitchell, Lai and Williams, J. Org. Chem., 44, 4733 (1979) to give a total yield of 50.2 g (62%) of 4-bromo-2,6-difluoroaniline, m.p.: 64°-66° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04873357 |
| Source dataset | uspto-grants-1989_10 |
| ORD ID | ord-80b6a799dfdf482ca36df2ca23b7b04b |
| Source note | uspto-grants-1989_10 |