HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 14390235, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Glycine ethyl ester | HCID 12176 | — |
| Reactant | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| Reactant | 4-chlorophenyl-3H-imidazo[4,5-b]pyridine-3-acetic acid | HCID 14390457 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 14390235 | HCID 14390235 | — |
Reaction Steps
Under nitrogen bubbling, a mixture of 2(4-chlorophenyl)-3H-imidazo[4,5-b]pyridine-3-acetic acid, 50.0 g (0.0174 mole) and 1,1'-carbonyldiimidazole (2.82 g, 0.0174 mole) in 150 ml of tetrahydrofuran was stirred at room temperature for 3 hrs. The ethyl glycinate (2.65 g, 0.019 mole) and triethylamine (1.92 g, 0.019 mole) were added dropwise and the reaction was allowed to stir at room temperature overnight.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04873251 |
| Source dataset | uspto-grants-1989_10 |
| ORD ID | ord-5cfbd790fbd7467aa16e809084cce33a |
| Source note | uspto-grants-1989_10 |