Triethylamine → HCID 19846218, compound

Participants

Reaction Steps

The compound (VII) (4.20 g) obtained above was suspended in water (40 ml) and 1,4-dioxane (10 ml) and triethylamine (6.0 ml) was further added. To this solution, a solution of 2-t-butoxycarbonyloxyimino-2-phenylacetnitrile (VIII) (3.06 g) in 1,4-dioxane (20 ml) was added at once at room temperature. The mixture was allowed to react at room temperature for 3 hours. Water (40 ml) and ethyl acetate (30 ml) were added to remove the unreacted compound (VIII). The aqueous layer was made weak acidic with citric acid. The separated oily product was extracted with ethyl acetate, followed by washing with water and drying. After distilling off the solvent in vacuo, the desired compound (I) (5.04 g), which was confirmed by NMR and IR analyses, was obtained in the amorphous state.

Provenance & Evidence